While desperately searching for Ashley, who remains in the hands of the Cabal, the Sanctuary team encounter a con artist named Kate Freelander. After her relationship with the Cabal went sour she gives Helen the location of a secret Cabal facility that may lead them to her Ashley.
Furious at being duped into a trap, Magnus takes on Kate, demanding information and complete access to her Cabal contacts. Now transformed into a Super Abnormal with devastating powers, Ashley and her newly cloned fighters begin their onslaught, destroying Sanctuaries in cities around the world.
Dr. Helen Magnus, her daughter Ashley, and the newest member to the Sanctuary, Dr. Zimmerman, travel to Northern Scotland to discover three women in an ancient crypt and bring them back to the Sanctuary for refuge and study.where she creates an oasis in the middle of Los Angeles. Christopher takes us to the Showcase House where he shows the master bedroom "before" the makeover and describes his plans for transformation. Christopher talks with Kazuko Hoshino of William Heffner Architects about creating altar spaces with items that are soothing and meaningful to you. Christopher takes us back to the showcase house master bedroom for a look at the progress being made in the makeover. Then he reviews the products from Loose Ends being used. Christopher reveals the finalized master bedroom in the showcase house in its tranquil splendor. In studio, he then demonstrates the technique for making a rolling bed table. Christopher shows some products from Sharper Image that provide soothing sounds and lights.
When a man arrives in the city dressed as a superhero and intent on fighting crime, his unusual strength and ability to fly grab the attention of Dr. Magnus. With the help of Will, Helen captures the man and runs tests on his DNA. The results, however, prove that he is not an abnormal, leaving the team confused as to where he got his powers from. Kate, meanwhile, tries to help her brother after he falls foul of a local crime boss.
A confused Dr. Magnus finds the Sanctuary and surrounding city has been destroyed, but she has no idea how it happened. While searching the remains she is pounced on by a vicious creature, leading to two armed men rescuing her and taking her to a nearby abandoned building. After being hosed down and dumped in a room on her own Magnus becomes fearful when an aggressive man, with a familiar face, enters.
Henry tries to determine why a seemingly docile domesticated abnormal suddenly turned violent after it attacks a research scientist.
Will goes up against the heads of the Sanctuary Network to defend Magnus who is charged with a shocking murder. But as the evidence stacks up against her, even Will has trouble finding a way to convincingly defend her innocence.
Magnus and Will try to retrieve a sea creature from the coast of Louisiana, but the Abnormal breaks lose in mid-flight, resulting in a crash landing that imperils the duo
Helen reunites with Jimmy who transports an elemental Abnormal to the Sanctuary. However they are tracked down by the underground Mobsters. Kate proves her loyalty and bonds with Jimmy over a common history they share
When Danny, an old friend of Will, goes missing, his wife contacts him asking for help. With the aid of Helen and Ashley, Will starts searching and they find themselves in an abandoned factory. There is no sign of people, but the team come to the conclusion that something took place there after they find dried blood and the drug epinephrine. They come to the conclusion that the building is being used as a place to train fighters.